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Tanshinone IIA can inhibit Angiotensin II-induced proliferation and autophagy of vascular smooth muscle cells via regulating the MAPK signaling pathway.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lu, Jingping Shan, Jinjun Liu, Ning Ding, Yao Yao Wang, Pei |
| Copyright Year | 2019 |
| Abstract | To examine the effect of tanshinone IIA on Angiotensin II (Ang II)-induced proliferation and autophagy in vascular smooth muscle cells (VSMCs) and the related mechanism. VSMCs were treated with Ang II with or without tanshinone IIA (1 μg/ml, 5 μg/ml and 10 μg/ml), and the proliferation, apoptosis in cells with different treatment were examined by MTT and flow cytometry methods. Moreover, the expression of autophagy related proteins and MAPK signaling molecules were examined by RT-qPCR and WB methods. Ang II induced significantly increase in the proliferation and autophagy of VSMCs, and the MAPK signaling was activated. Tanshinone IIA can attenuate Ang II-induced effects via down-regulating the MAPK signaling pathway. Tanshinone IIA can inhibit Ang II-induced proliferation and autophagy of VSMCs via regulating the MAPK signaling pathway. |
| File Format | PDF HTM / HTML |
| DOI | 10.1248/bpb.b19-00053 |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/bpb/42/11/42_b19-00053/_pdf/-char/en |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/bpb/advpub/0/advpub_b19-00053/_pdf/-char/en |
| PubMed reference number | 31391347 |
| Alternate Webpage(s) | https://doi.org/10.1248/bpb.b19-00053 |
| Journal | Medline |
| Journal | Biological & pharmaceutical bulletin |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
