Melanosis and associated tumors in transgenic mice.

Content Provider	Semantic Scholar
Author	Klein-Szanto, Andres J. P. Bradl, Monika Porter, Susan Mintz, Beatrice
Copyright Year	1991
Abstract	Melanosis was found to various extents in a wide array of tissues of all 23 autopsied mice whose transgene consisted of the tyrosinase promoter fused to the simian virus 40 early-region oncogenic sequences. Pigmentation in a given animal was attributable to any or all of the following; an increase in numbers of some normally pigmented cells of neural crest origin (a result compatible with early stages of transformation); elicitation of melanin synthesis in some cells that normally have little melanin, or none at all (the latter possibly signaling metaplasia); unusual intercellular transfer of pigment granules from melanocytes into certain normally unpigmented epithelia and endothelia; and profusion of melanin-phagocytizing cells. Neoplasms, occasionally also containing melanin, arose in association with some of these melanotic tissues and included three choroid plexus tumors, three endocardial tumors, two peripheral nerve sheath tumors (schwannomas), two cochlear tumors, two pineal gland tumors, one salivary gland tumor, and one nasal mucosa tumor. These apparently originated independently of the ocular and cutaneous melanomas found in the same animals. The events involved in melanosis may thus contribute to neoplastic conversion.
Starting Page	1
Ending Page	3
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.pnas.org/content/88/1/169.full.pdf
PubMed reference number	1846037v1
Volume Number	88
Issue Number	1
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Subject Keyword	Body tissue Choroid Plexus Neoplasms Cochlear structure Cutaneous Melanoma Endocardial Neoplasm Endocardium Granule Melanins Melanosis coli Metaplasia Nerve Sheath Tumors Neural Crest Neurilemmoma Peripheral Nerve Sheath Neoplasm Peripheral Nerves Pineal Gland Neoplasm Salivary Gland Neoplasms Salivary Glands Simian virus 40 Structure of mucous membrane of nose melanin biosynthetic process melanocyte
Content Type	Text
Resource Type	Article