NDLI: Two cases of mantle cell lymphoma mimicking marginal zone lymphoma

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Two cases of mantle cell lymphoma mimicking marginal zone lymphoma

Content Provider	Semantic Scholar
Author	Xu, Xiangdong Wang, Huan-You Rashidi, Hooman H. Wong, Anna
Copyright Year	2012
Abstract	Mantle cell lymphoma (MCL) is a B cell lymphoma with four morphologic variants recognized by the current World Health Organization classification. MCL mimicking marginal zone lymphoma (MZL) (MCL mimicking MZL) is the rarest variant and could be a potential diagnostic pitfall due to its deceiving “monocytoid” appearance. We report two cases of extranodal MCL mimicking MZL occurring at different sites—the oropharynx and the rectosigmoid colon. Both cases showed unexpected diffuse submucosal lymphoid infiltration of small- to medium-sized lymphocytes with focal monocytoid appearance. Immunohistochemistry showed the presence of an abnormal CD5(−)/CD10(−) B cell population expressing cyclin D1. The diagnosis of MCL was further substantiated by cytogenetic evidence of t(11;14)(q13;q32). Ki-67 proliferation indexes of both cases were low. In summary, MCL mimicking MZL may have unusual morphologic and immunophenotypic characteristics that could be a diagnostic pitfall.
Starting Page	335
Ending Page	340
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1007/s12308-012-0147-7
Volume Number	5
Alternate Webpage(s)	https://rd.springer.com/content/pdf/10.1007/s12308-012-0147-7.pdf
Alternate Webpage(s)	https://doi.org/10.1007/s12308-012-0147-7
Journal	Journal of Hematopathology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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