EFECTO DE ATORVASTATINA EN CÁNCER DE COLON INDUCIDO EN Rattus norvegicus var. albinus * Y SU ESTUDIO HISTOPATOLÓGICO EFFECT OF ATORVASTATIN ON COLON CANCER INDUCED IN Rattus norvegicus var. albinus AND ITS HISTOPATHOLOGY STUDY

Content Provider	Semantic Scholar
Author	Maria, Ana Vásquez, Guevara
Copyright Year	2013
Abstract	espanolEl objetivo del estudio fue determinar el efecto de atorvastatina en cancer de colon inducido en Rattus norvegicus var. Albinus. Se utilizaron 24 especimenes machos adultos divididos aleatoriamente en cuatro grupos de seis especimenes cada uno: blanco, control y problemas I y II (que recibieron 0,1143 mg/dia/200 g, equivalente a 40 mg/dia/70 kg y de 0,2286 mg/dia/200 g, equivalente a 80 mg/dia/70 kg de atorvastatina). Se utilizo 1,2dimetilhidrazina para inducir cancer de colon en los grupos control y problema a la dosis de 21 mg/kg p.c/ semana, via subcutanea durante 18 semanas. Los parametros que se utilizaron para comprobar el efecto fueron: las observaciones histopatologicas microscopicas y macroscopicas, considerandose el numero y tamano (en milimetros) de las tumoraciones, su ubicacion y el diagnostico de tipo de lesion en el modelo experimental. Los resultados mostraron diferencia significativa entre los grupos problema y el grupo control (p EnglishThe aim of the study was to determine the effect of atorvastatin in colon cancer induced in albino rats. For this purpose, 24 adult males of Rattus norvegicus var. albinus were randomly divided into four groups of six specimens each: white, control and problems I and II (that received 0,1143 mg/day/200 g equivalent 40 mg/day/70 kg and 80 mg/day/70 kg equivalent 0,2286 mg/day/200 g to atorvastatin). 1,2-dimethylhydrazine was used to induce colon cancer in control and problem groups to doses of 21 mg / kg bw / week subcutaneously for 18 weeks. The parameters used to test the effect were: microscopic and macroscopic histopathological findings considering the number and size (in millimeters) of tumors, location and diagnosis of type of injury in an experimental model. The results showed a significant difference between problem and control groups (p
File Format	PDF HTM / HTML
DOI	10.21895/incres.2013.v4n1.09
Alternate Webpage(s)	http://revistas.uladech.edu.pe/index.php/increscendo/article/download/25/25
Alternate Webpage(s)	https://doi.org/10.21895/incres.2013.v4n1.09
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article