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Two families of novel, receptor-type selective antagonists: What do they tell us?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rónai, András Z. Boty'anszki, J'anos Orosz, György Medzihradszky, Kálmán |
| Copyright Year | 1994 |
| Abstract | We followed the design strategy of opioid core --spacer/conformational adjuvant-- type-specific «label/signature» to produce opioid peptide antagonists specific for the δ or κ receptor type. The first project was successful (1); the second was based on a pentapeptide sequence (Tyr-Lys-Lys-Trp-Trp-NH 2 ) found in cobrotoxin (see Orosz et al., this volume). This project is at the beginning, but promising. Besides producing the antagonists, we wanted to find the simplest address - and message (2) core which still contains full, receptor type-specific information. Since - erroneously- we have regarded the Tyr-Pro sequence as the opioid core, we sought in this direction. We have a synthetic dipeptide, H-Tyr(O t Bu)-D-Pro-OH with 6 receptor agonist characteristics |
| Starting Page | s57 |
| Ending Page | s58 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0167-0115(94)90239-9 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0167011594902399 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0167011594902399?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0167-0115%2894%2990239-9 |
| Volume Number | 53 |
| Journal | Regulatory Peptides |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
