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Invasive serogroup B Neisseria meningitidis in Quebec, Canada, 2003 to 2010: persistence of the ST-269 clone since it first emerged in 2003.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhou, Jianwei Lefebvre, Brigitte Deng, Saul Gilca, Rodica Deceuninck, Geneviève Law, Dennis K. S. Wals, P. De Tsang, Raymond S. W. |
| Copyright Year | 2012 |
| Abstract | In the era after the introduction of the meningococcal serogroup C conjugate vaccine, from 1 January 2003 to 31 December 2010, serogroup B meningococci were the major cause of invasive meningococcal disease in the province of Québec, Canada, being responsible for 72% of all meningococcal disease cases. Of the 334 invasive serogroup B Neisseria meningitidis strains analyzed, 53.9% belonged to the ST-269 clonal complex (CC). Since it first emerged in 2003, the percentage of invasive serogroup B isolates that belonged to the ST-269 CC had increased from 35% in 2003 to 76% in 2010. Among the 180 meningococci in the ST-269 CC, 91.7% belonged to a single ST (ST-269). The most common PorA genotypes identified in the ST-269 CC were (i) VR1 19-1, VR2 15-11, VR3 36 (84%) and (ii) VR1 18-7, VR2 9, VR3 35-1 (9%). Cases of invasive disease due to the ST-269 CC were commonly found in those aged 11 to 19 years (30.5%) and 20 to 40 years (25.5%). Meningococci of the ST-269 CC were uncommon in other Canadian provinces. In contrast to the ST-269 CC, invasive serogroup B meningococci that belonged to the ST-41/44 CC were much more diverse genetically. However, one ST (ST-571), which is uncommon in the United States, accounted for 35% of all cases due to this CC. The current finding suggests that the ST-269 clone may indeed represent an emerging hypervirulent clone of meningococci. |
| Starting Page | 163 |
| Ending Page | 170 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jcm.asm.org/content/50/5/1545.full.pdf |
| PubMed reference number | 22337990v1 |
| Alternate Webpage(s) | https://doi.org/10.1128/JCM.06835-11 |
| DOI | 10.1128/JCM.06835-11 |
| Journal | Journal of clinical microbiology |
| Volume Number | 50 |
| Issue Number | 5 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Clomiphene Clone Genotype Immunostimulating conjugate (antigen) Meningococcal Infections Neisseria meningitidis Serogroup Vaccines, Conjugate meningococcal polysaccharide vaccine (MPSV4) |
| Content Type | Text |
| Resource Type | Article |
