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Serum cystatin C advantageous compared with serum creatinine in the detection of mild but not severe diabetic nephropathy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Christensson, Anders Grubb, Anders Norrgren, Kristina Sterner, Gunnar Sundkvist, Göran |
| Copyright Year | 2004 |
| Abstract | OBJECTIVE To determine whether serum cystatin C is more accurate than serum creatinine in the detection of diabetic nephropathy, also after adjustment for age. METHODS Forty-one patients with type 1 and 82 patients with type 2 diabetes were evaluated with serum creatinine, serum cystatin C, and (51)Cr-EDTA clearance (reference method). Cystatin C was measured by a particle-enhanced turbidimetric method and creatinine by an enzymatic method. Statistical estimations were performed both without and with age adjustment created by z-scores for (51)Cr-EDTA clearance, creatinine, and cystatin C. The cut-off levels for glomerular filtration rate (GFR) ((51)Cr-EDTA clearance) were 60 and 80 mL min(-1) 1.73 m(-2), respectively, in absolute values and 80, 90 and 95% CIs, respectively, in age-adjusted values (z-scores). RESULTS Estimations without age adjustment showed significantly (P = 0.0132) closer correlation for cystatin C (r = 0.817) versus (51)Cr-EDTA clearance as compared with creatinine (r = 0.678). However, when using age-adjusted values, the correlation for cystatin C and creatinine, respectively, versus (51)Cr-EDTA clearance did not differ. When comparing the diagnostic utilities for serum cystatin C versus serum creatinine in manifest renal impairment (GFR < 60 mL min(-1) 1.73 m(-2) or z-scores <-1.28 SD), there were no significant differences between the two markers whether age adjusted or not. However, for diagnosing mild nephropathy (GFR < 80 mL min(-1) 1.73 m(-2) or z-score -0.84 SD), serum cystatin C is significantly more useful. CONCLUSIONS Serum cystatin C performed better compared with serum creatinine even when measured enzymatically, to detect mild diabetic nephropathy. However, serum creatinine was as efficient as serum cystatin C to detect advanced diabetic nephropathy. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://portal.research.lu.se/portal/files/4443690/624167.pdf |
| Alternate Webpage(s) | http://lup.lub.lu.se/search/ws/files/4443690/624167.pdf |
| PubMed reference number | 15554952v1 |
| Volume Number | 256 |
| Issue Number | 6 |
| Journal | Journal of internal medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Creatinine measurement, serum (procedure) Cystatin C (substance) Cystatins Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Diabetic Nephropathy EDTA Clearance Edetic Acid Eighty Glomerular Filtration Rate Kidney Diseases Patients Renal Insufficiency |
| Content Type | Text |
| Resource Type | Article |
