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Comparison of conditioned taste aversions produced by MDMA and d-amphetamine
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lin, Hui Qiang Atrens, Dale M. Christie, Macdonald J. Jackson, David M. McGregor, Iain S. |
| Copyright Year | 1993 |
| Abstract | Many drugs of abuse such as d-amphetamine support the development of taste aversion in a conditioned taste aversion paradigm. However, it has yet to be established whether methylenedioxymethamphetamine (MDMA), an amphetamine-like stimulant, has this property. A direct comparison was made between MDMA and d-amphetamine over a dose range of 0.125-2.0 mg/kg (SC). Two pairings of either drug with saccharin produced dose-related taste aversions to saccharin that were retained for at least three successive testing trials. The minimally effective dose was 1 mg/kg for MDMA and 0.5 mg/kg for d-amphetamine. The relative potency of MDMA to amphetamine was 4.5, similar to that previously reported for drug discrimination and self-stimulation. |
| Starting Page | 153 |
| Ending Page | 156 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0091-3057(93)90333-O |
| PubMed reference number | 7902981 |
| Journal | Medline |
| Volume Number | 46 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/009130579390333O |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/009130579390333O?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0091-3057%2893%2990333-O |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
