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Interrelationship of thermal and sleep-wakefulness changes elicited from the medial preoptic area in rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Datta, Sukdeb Kumar, Velayudhan Mohan Chhina, Gulzar Singh Singh, Betty |
| Copyright Year | 1988 |
| Abstract | The study investigated the possible interrelationship between changes in sleep-wakefulness and body temperature, primarily induced by manipulation of the noradrenergic system in the medial preoptic area. Saline, norepinephrine, and its alpha- and beta-blockers were injected in the medial preoptic area and in some control areas of rats, during their sleeping and active periods. 5-Hydroxytryptamine was injected in the medial preoptic area in another group of animals. Simultaneous changes in sleep-wakefulness and the body temperature were continuously recorded. Norepinephrine produced hypothermia and arousal, whereas alpha-adrenergic blockers induced hyperthermia and sleep. These changes in body temperature and in sleep-wakefulness did not follow an identical time course. 5-Hydroxytryptamine induced hyperthermia without affecting sleep-wakefulness. It is suggested that there are different neuronal mechanisms in the medial preoptic area that bring about the drug-induced changes in temperature and sleep-wakefulness. |
| Starting Page | 40 |
| Ending Page | 50 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0014-4886(88)90199-9 |
| PubMed reference number | 3350096 |
| Journal | Medline |
| Volume Number | 100 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0014488688901999 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0014488688901999?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0014-4886%2888%2990199-9 |
| Journal | Experimental Neurology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
