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Permeation-driven flow in poly(dimethylsiloxane) microfluidic devices.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Randall, Greg C. Doyle, Patrick S. |
| Copyright Year | 2005 |
| Abstract | Poly(dimethylsiloxane) is currently the material of choice for rapidly fabricating microfluidic devices. As the size of these devices decreases, a significant hydrodynamic flow is generated due to permeation of fluid through the channel walls. We develop a theoretical model verified by single bead tracking experiments, which demonstrates that large flow rates (>10 microm/s) can be passively generated in a straight microchannel filled with water. Realizing that this flow may be unwanted in some applications, we present a method to eliminate it by inhibiting mass transfer of water into the poly(dimethylsiloxane) walls. Furthermore, we explore applications to harness this passively generated flow inside a microfluidic device such as bead stacking, chemical concentration, and passive pumping. |
| File Format | PDF HTM / HTML |
| DOI | 10.1073/pnas.0503287102 |
| PubMed reference number | 16043719 |
| Journal | Medline |
| Volume Number | 102 |
| Issue Number | 31 |
| Alternate Webpage(s) | http://web.mit.edu/doylegroup/pubs/randall-PNAS2005.pdf |
| Alternate Webpage(s) | https://doi.org/10.1073/pnas.0503287102 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
