NDLI: Efficacy and Safety Outcomes of Extended Criteria Donor Kidneys by Subtype: Subgroup Analysis of BENEFIT‐EXT at 7 Years After Transplant

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Efficacy and Safety Outcomes of Extended Criteria Donor Kidneys by Subtype: Subgroup Analysis of BENEFIT‐EXT at 7 Years After Transplant

Content Provider	Semantic Scholar
Author	Florman, Sandy Becker, T. Bresnahan, Brian W. Chevaile-Ramos, Alejandro Carvalho, D. Grannas, Gerit Muehlbacher, Ferdinand O'connell, Philip J. Meier-Kriesche, Herwig-Ulf Larsen, Christian P.
Copyright Year	2017
Abstract	The phase III Belatacept Evaluation of Nephroprotection and Efficacy as First-Line Immunosuppression Trial-Extended Criteria Donors Trial (BENEFIT-EXT) study compared more or less intensive belatacept-based immunosuppression with cyclosporine (CsA)-based immunosuppression in recipients of extended criteria donor kidneys. In this post hoc analysis, patient outcomes were assessed according to donor kidney subtype. In total, 68.9% of patients received an expanded criteria donor kidney (United Network for Organ Sharing definition), 10.1% received a donation after cardiac death kidney, and 21.0% received a kidney with an anticipated cold ischemic time ≥24 h. Over 7 years, time to death or graft loss was similar between belatacept- and CsA-based immunosuppression, regardless of donor kidney subtype. In all three donor kidney cohorts, estimated mean GFR increased over months 1-84 for belatacept-based treatment but declined for CsA-based treatment. The estimated differences in GFR significantly favored each belatacept-based regimen versus the CsA-based regimen in the three subgroups (p < 0.0001 for overall treatment effect). No differences in the safety profile of belatacept were observed by donor kidney subtype.
Starting Page	180
Ending Page	190
Page Count	11
File Format	PDF HTM / HTML
DOI	10.1111/ajt.13886
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/88/AJT-17-180.PMC5215636.pdf
PubMed reference number	27232116
Alternate Webpage(s)	https://doi.org/10.1111/ajt.13886
Journal	Medline
Volume Number	17
Journal	American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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