NDLI: Low prevalence of insulin resistance among HIV-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in Thailand.

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Low prevalence of insulin resistance among HIV-infected children receiving nonnucleoside reverse transcriptase inhibitor-based highly active antiretroviral therapy in Thailand.

Content Provider	Semantic Scholar
Author	Lee, Brian P. Aurpibul, Linda Sirisanthana, Virat Mangklabruks, Ampica Sirisanthana, Thira Puthanakit, Thanyawee
Copyright Year	2009
Abstract	BACKGROUND Highly active antiretroviral therapy (HAART) is reported to cause insulin resistance among adults, but effects on children are less clear. We attempted to describe the prevalence of insulin resistance among HIV-infected children receiving HAART. METHODS Insulin resistance was assessed at 96 weeks of treatment with nonnucleoside reverse transcriptase inhibitor (NNRTI)-based HAART (nevirapine or efavirenz with stavudine and lamivudine) among children in Chiang Mai, Thailand. Insulin resistance was defined as homeostasis model assessment for insulin resistance (HOMA-IR) >/=3.16, fasting c-peptide >/=4.40 ng/mL or fasting insulin >/=25.0 muU/mL. Impaired fasting glucose (IFG) was defined as glucose >/=110 mg/dL. Measurements were analysed for associations with age, lipodystrophy, treatment regimen and clinical data. RESULTS The prevalence of insulin resistance was 6.5%; no child had IFG. Those with insulin resistance were older with higher body mass index. Children >/=10 years had higher HOMA-IR, c-peptide and insulin, but no difference was seen in the frequency of insulin resistance. No associations between insulin resistance and lipodystrophy or treatment regimen were detected. CONCLUSIONS Insulin resistance is uncommon among children receiving NNRTI-based HAART and is unrelated to lipodystrophy.
Starting Page	164A
Ending Page	164A
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.med.cmu.ac.th/dept/pediatrics/04-divisions_home_thai/09-id-home/ID-2-hiv/02-res_fulltext/2009/09_1_Insulin_resist_HIVmed_2009.pdf
PubMed reference number	19018877v1
Alternate Webpage(s)	https://doi.org/10.1111/j.1468-1293.2008.00653.x
DOI	10.1111/j.1468-1293.2008.00653.x
Journal	HIV medicine
Volume Number	10
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	Antiretroviral Therapy, Highly Active Antiretroviral therapy Attempt C-Peptide Glucose Metabolism Disorders HIV Infections IFNG gene Insulin Resistance Lamivudine Lipodystrophy Low sodium diet Mental association Nevirapine Non-nucleoside Reverse Transcriptase Inhibitor RNA-Directed DNA Polymerase Reverse Transcriptase Inhibitors Stavudine efavirenz insulin, isophane
Content Type	Text
Resource Type	Article

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