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Evaluation of a high framerate multi-exposure laser speckle contrast imaging setup
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hultman, Martin Fredriksson, Ingemar Strömberg, Tomas Larsson, Marcus |
| Copyright Year | 2018 |
| Abstract | We present a first evaluation of a new multi-exposure laser speckle contrast imaging (MELSCI) system for assessing spatial variations in the microcirculatory perfusion. The MELSCI system is based on a 1000 frames per second 1-megapixel camera connected to a field programmable gate arrays (FPGA) capable of producing MELSCI data in realtime. The imaging system is evaluated against a single point laser Doppler flowmetry (LDF) system during occlusionrelease provocations of the arm in five subjects. Perfusion is calculated from MELSCI data using current state-of-the-art inverse models. The analysis displayed a good agreement between measured and modeled data, with an average error below 6%. This strongly indicates that the applied model is capable of accurately describing the MELSCI data and that the acquired data is of high quality. Comparing readings from the occlusion-release provocation showed that the MELSCI perfusion was significantly correlated (R=0.83) to the single point LDF perfusion, clearly outperforming perfusion estimations based on a single exposure time. We conclude that the MELSCI system provides blood flow images of enhanced quality, taking us one step closer to a system that accurately can monitor dynamic changes in skin perfusion over a large area in real-time. |
| File Format | PDF HTM / HTML |
| DOI | 10.1117/12.2286248 |
| Volume Number | 10505 |
| Alternate Webpage(s) | http://www.diva-portal.org/smash/get/diva2:1221847/FULLTEXT02.pdf |
| Alternate Webpage(s) | https://doi.org/10.1117/12.2286248 |
| Journal | BiOS |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
