NDLI: New derivatives of aryl-propionic acid. Synthesis and biological evaluation.

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New derivatives of aryl-propionic acid. Synthesis and biological evaluation.

Content Provider	Semantic Scholar
Author	Vasincu, Ioana Mirela Apotrosoaei, Maria Tuchiluş, Cristina Gabriela Pânzariu, Andreea Dragostin, Oana Maria Lupaşcu, Dan Profire, Lenuța
Copyright Year	2013
Abstract	AIM To design new derivatives of aryl-propionic acid with potential antibacterial and antioxidant activity. MATERIAL AND METHODS New hydrazone of ibuprofen (2-(4-isobutylphenyl)propionic acid) have been synthesized by reaction of ethyl ester of ibuprofen with hydrazine hydrate and then condensation of corresponding hydrazide with various aromatic aldehydes. RESULTS The synthesized compounds were screened for their antibacterial activity against Gram positive (Staphylococcus aureus ATCC 25923, Sarcinalutea ATCC 9341, Bacillus cereus ATCC 14579, Bacillus subtilis) and Gram negative bacterial strains (Escherichia coli ATCC 25922). Some of them were found to have good antibacterial activity. The antioxidant activity of these compounds was also tested using the total antiox idant capacity test. CONCLUSIONS The chemical modulations performed on ibuprofen structure have a good influence on the biological activity of the synthesized compounds.
File Format	PDF HTM / HTML
PubMed reference number	24340542
Journal	Medline
Volume Number	117
Issue Number	2
Alternate Webpage(s)	https://www.revmedchir.ro/index.php/revmedchir/article/download/912/780/
Journal	Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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