NDLI: Universidade Federal Do Rio Grande Do Norte Centro De Ciências Da Saúde Programa De Pós-graduação Em Ciências Da Saúde

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Universidade Federal Do Rio Grande Do Norte Centro De Ciências Da Saúde Programa De Pós-graduação Em Ciências Da Saúde

Content Provider	Semantic Scholar
Author	Batista, Gilmário Ricarte
Copyright Year	2008
Abstract	Purpose: Many patients with metastatic bone disease have t o use radiopharmaceuticals associated with chemotherapy to relieve bone pain. The aim of this study was to assess the influence of docetaxel on the biodistribution of sa marium-153-EDTMP in bones and other organs of rats. Methods: Wistar male rats were randomly allocated into 2 g roups of 6 rats each. The DS (docetaxel/samarium) group received docetaxe l (15 mg/kg) intraperitoneally in two cycles 11 days apart. The S (samarium/control) grou p ats were not treated with docetaxel. Nine days after chemotherapy, all the rats were injected with 0.1ml of samarium-153-EDTMP via orbital plexus (25 μCi). After 2 hours, the animals were killed and sam ples of the brain, thyroid, lung, heart, stomach, colon, liver, kidney and both femurs were removed. The percentage radioactivity of each sample (% ATI/g) was determin ed in an automatic gamma-counter (Wizard-1470, Perkin-Elmer, Finland). Results: On the 9 day after the administration of the 2 nd chemotherapy cycle, the rats had a significant weig ht loss (314.50±22.09g) compared (p<0.5) to pre-treatment weight (353.66± 22.8). The % ATI/g in the samples of rats treated with samarium153-EDTMP had a significant reduction in the right femur, left femur, kidney, liver and lungs of animals treated with docetaxel, compared to the con trol rats. Conclusion: The combination of docetaxel and samarium-153-EDTMP was associated wit h a lower response rate in the biodistribution of the radiopharmaceutical to targe ted tissues. Further investigation into the impact of docetaxel on biodistribution of samarium153-EDTMP would complement the findings of this study.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://repositorio.ufrn.br:8080/jspui/bitstream/123456789/13408/1/AptidaoF%C3%ADsicaPsicol%C3%B3gica_OliveiraJunior_2013.pdf
Alternate Webpage(s)	https://repositorio.ufrn.br/jspui/bitstream/123456789/13158/1/ArthurVN.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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