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The contribution of TGF-β in Epithelial-Mesenchymal Transition (EMT): Down-regulation of E-cadherin via snail.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yu, Hua-Jun Shen, Yafen Zhou, Fengling Liu, Xiaoxiao |
| Copyright Year | 2015 |
| Abstract | UNLABELLED TGF-β plays a central role in epithelial-mesenchymal transition (EMT), which is a highly conserved and reversible process that governs tumor development, invasion and metastasis. Through this transition, the epithelial cell acquires a migratory behavior which allows it to move away from the cell community and to integrate into the surrounding tissue. The cells lost epithelial phenotypes including the change of cell polarity and the loss of specialized cell-cell contacts, which related with the shortage of E-cadherin directly. The increasing reports indicated that TGF-β down-regulated the expression of E-cadherin through snail signaling pathway, which played an important role in the development of EMT. In this review, we summarized the contribution of TGF-β in EMT and discussed the molecular mechanism of snail signaling participating in the regulation of E-cadherin triggered by TGF-β. KEYWORDS TGF-β, Epithelial-mesenchymal-transition (EMT), snail family, E-cadherin. |
| Starting Page | 1 |
| Ending Page | 15 |
| Page Count | 15 |
| File Format | PDF HTM / HTML |
| DOI | 10.4149/neo_2015_002 |
| PubMed reference number | 25563362 |
| Journal | Medline |
| Volume Number | 62 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://www.elis.sk/download_file.php?product_id=4026&session_id=sh8fr76gqpn7hfuhuk2iipj305 |
| Alternate Webpage(s) | https://doi.org/10.4149/neo_2015_002 |
| Journal | Neoplasma |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
