Women and ARV-based prevention: opportunities and challenges

Content Provider	Semantic Scholar
Author	Geary, Cynthia Waszak Bukusi, Elizabeth Ann Straten, Ariane Van Der Stadler, J. Luecke, Ellen H. Laborde, Nicole D. Hartmann, Miriam Corneli, Amy L. McKenna, Kevin Ahmed, Khatija Odhiambo, Jacob Skhosana, Joseph Wang, Monica Agot, Kawango Mastro, Timothy D. Sista, Nirupama Deshmane Abdool-Karim, Quarraisha Lanham, Michele Wilcher, Rose Montgomery, Elizabeth T. Pool, Robert Schuler, S. Lenzi, Rachel Queen, Kathleen M. Mac Owen, Derek H. Amico, K. Rivet Morrow, Kathleen M. Moench, Thomas R. Friedland, Barbara Kaaya, Sylvia F. Kaale, Anna Minja, Anna Bangapi, Doreen Kalungura, Happy Headley, Jennifer Baumgartner, Joy Noel Sidibe, Sekou Pack, Allison P. Ryan, Elizabeth Bockh, Emily Githuka, George N. Mack, Natasha Evens, Emily McDonald Tolley, Elizabeth E. Brelsford, Kate Mackenzie, Caroline Milford, Cecilia Smit, Jennifer Ann Kimani, Joshua Woodsong, Cynthia Mutsambi, John Michael Ntshele, Smangalisa Modikoe, Peggy Lin, Amy Hsiu-Ti Breger, Tiffany L. Barnhart, Matthew Kim, Ae Kyung Vangsgaard, Charlotte Harris, Emily Lusti-Narasimhan, Manjula Khosla, Rajat Baggaley, Rachel Clare Temmerman, Marleen McGrory, Elizabeth Farley, Tim
Copyright Year	2014
Abstract	ARV-based HIV prevention methods available in pill, gel or ring formulations (broadly referred to as microbicides) offer the possibility of protection against HIV for women who find it difficult because they cannot ask their partners to use condoms or even refuse sex. Partial efficacy of ARV-based medications has been demonstrated in a number of clinical trials around the world among various populations, building the evidence that ARV-based technologies will contribute to reducing the AIDS epidemic worldwide. Disappointing results, however, from two trials in sub-Saharan Africa, where poor adherence contributed to study closure due to futility, have raised questions about whether women at the centre of the epidemic are able to effectively use products that require routine use. Also, there are fears by some of risk compensation by decreased condom use because of the availability of microbicides when only partial efficacy has been demonstrated in microbicide trials to date. Of note, sub-analyses of biologic measures of adherence in trials where this was possible have shown a strong correlation between good adherence and efficacy, reinforcing the necessity of good adherence. Research conducted in conjunction with clinical trials and post-trials in advance of possible rollout of ARV-based products have examined social and cultural factors, gender-related and otherwise, influencing adherence and other aspects of women’s use of products. These include HIV stigma, women’s perception of risk, partner and community influences and the differing needs of women in various stages of life and in different circumstances. It is the purpose of this supplement to give voice to the needs of women who can benefit from woman-initiated methods by presenting research results and commentary to contribute to the global conversation about optimizing women’s experience with ARV-based prevention.
Starting Page	148
Ending Page	148
Page Count	1
File Format	PDF HTM / HTML
PubMed reference number	4165039
Volume Number	17
Language	English
Access Restriction	Open
Subject Keyword	Acquired Immunodeficiency Syndrome Biological Factors Condoms, Male HIV Infections Microbicides Population Published Comment XM1219 Armed Robotic Vehicle eyespot apparatus
Content Type	Text
Resource Type	Article