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Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huang, Bo Pan, Ping-Ying Li, Qingsheng Sato, Alice I. Levy, David E. Bromberg, Jonathan S. Divino, Celia M. Chen, Shu-Hsia |
| Copyright Year | 2006 |
| Abstract | The accumulation of myeloid suppressor cells (MSCs) is associated with immune suppression in tumor-bearing mice and in cancer patients. The suppressive activity of MSC correlates with the expression of the myeloid markers Gr-1, CD115 (macrophage colony-stimulating factor receptor), and F4/80. Gr-1(+)CD115(+) MSCs, in addition to being able to suppress T-cell proliferation in vitro, can induce the development of Foxp3(+) T regulatory cells (Treg) in vivo, which are anergic and suppressive. Furthermore, the secretion of interleukin (IL)-10 and transforming growth factor-beta by Gr-1(+)CD115(+) MSCs was induced and enhanced, respectively, on IFN-gamma stimulation. The development of Treg requires antigen-associated activation of tumor-specific T cells, depends on the presence of IFN-gamma and IL-10, and is independent of the nitric oxide-mediated suppressive mechanism by MSC. Our data provide evidence that Gr-1(+)CD115(+) MSC can mediate the development of Treg in tumor-bearing mice and show a novel immune suppressive mechanism by which MSCs can suppress antitumor responses. |
| File Format | PDF HTM / HTML |
| DOI | 10.1158/0008-5472.CAN-05-1299 |
| PubMed reference number | 16424049 |
| Journal | Medline |
| Volume Number | 66 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://cancerres.aacrjournals.org/content/canres/66/2/1123.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1158/0008-5472.CAN-05-1299 |
| Journal | Cancer research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
