NDLI: Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension.

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Bosentan therapy for inoperable chronic thromboembolic pulmonary hypertension.

Content Provider	Semantic Scholar
Author	Hoeper, Marius M. Kramm, Thorsten Wilkens, Heinrike Schulze, Christine E. Schäfers, Hans Joachim Welte, Tobias Mayer, Eckhard
Copyright Year	2005
Abstract	STUDY OBJECTIVES We performed an open-label multicenter study to evaluate the safety and efficacy of the dual endothelin receptor antagonist bosentan in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). PATIENTS Nineteen patients with inoperable CTEPH were enrolled. MEASUREMENTS The primary end point was a change in pulmonary vascular resistance (PVR). Secondary end points included 6-min walk test, peak oxygen uptake (V(O2)), New York Heart Association functional class, serum levels of N-terminal-pro brain natriuretic peptide (NT-pro-BNP), and various other hemodynamic parameters. RESULTS After 3 months of treatment with bosentan, PVR decreased from 914 +/- 329 to 611 +/- 220 dyne.s.cm(-5) (p < 0.001). Functional class and peak V(O2) remained unchanged, but 6-min walk distance increased from 340 +/- 102 to 413 +/- 130 m (p = 0.009), and serum NT-pro BNP levels improved from 2,895 +/- 2,620 to 2,179 +/- 2,301 (p = 0.027). One patient died, presumably from influenza A infection, and another patient experienced progressive fluid retention despite reduction of PVR. Other than that, treatment was well tolerated by all patients. CONCLUSIONS This open-label pilot trial suggests that bosentan may offer a therapeutic option for patients with inoperable CTEPH. Randomized controlled trials are warranted to confirm these findings.
File Format	PDF HTM / HTML
DOI	10.1378/chest.128.4.2363
PubMed reference number	16236895
Journal	Medline
Volume Number	128
Issue Number	4
Alternate Webpage(s)	http://journal.publications.chestnet.org/pdfaccess.ashx?url=/data/journals/chest/22032/2363.pdf
Alternate Webpage(s)	https://doi.org/10.1378/chest.128.4.2363
Journal	Chest
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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