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The synthesis of chiral β-aryl-α,β-unsaturated amino alcohols via a Pd-catalyzed asymmetric allylic amination.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Quan, Mao Can Butt, Nicholas A. Shen, Jiefeng Shen, Kaiji Liu, Delong Zhang, Wanbin |
| Copyright Year | 2013 |
| Abstract | Chiral β-aryl-α,β-unsaturated amino alcohols were synthesized via a Pd-catalyzed asymmetric allylic amination of 4-aryl-1,3-dioxolan-2-one using planar chiral 1,2-disubstituted ferrocene-based phosphinooxazolines as ligands. Under the optimized reaction conditions, a series of substrates were examined and the products were obtained in good to excellent yields (up to 92%) and enantioselectivities (up to 98% ee) under mild reaction conditions. The desired products were determined to be of (R)-configuration and could subsequently be transformed into compounds with interesting biological activity using simple transformations. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c3ob41642a |
| PubMed reference number | 24077558 |
| Journal | Medline |
| Volume Number | 11 |
| Issue Number | 42 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ob/c3/c3ob41642a/c3ob41642a.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/c3ob41642a |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
