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Regulation of carnitine palmitoyltransferase I (CPT-Iα) gene expression by the peroxisome proliferator activated receptor gamma coactivator (PGC-1) isoforms
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sadana, Prabodh Zhang, Yi Dong Song, Shulan Cook, George A. Park, Edwards Amasa |
| Copyright Year | 2007 |
| Abstract | The peroxisome proliferator activated receptor gamma coactivators (PGC-1) have important roles in mitochondrial biogenesis and metabolic control in a variety of tissues. There are multiple isoforms of PGC-1 including PGC-1alpha and PGC-1beta. Both the PGC-1alpha and beta isoforms promote mitochondrial biogenesis and fatty acid oxidation, but only PGC-1alpha stimulates gluconeogenesis in the liver. Carnitine palmitoyltransferase I (CPT-I) is a key enzyme regulating mitochondrial fatty acid oxidation. In these studies, we determined that PGC-1beta stimulated expression of the "liver" isoform of CPT-I (CPT-Ialpha) but that PGC-1beta did not induce pyruvate dehydrogenase kinase 4 (PDK4) which is a regulator of pyruvate metabolism. The CPT-Ialpha gene is induced by thyroid hormone. We found that T3 increased the expression of PGC-1beta and that PGC-1beta enhanced the T3 induction of CPT-Ialpha. The thyroid hormone receptor interacts with PGC-1beta in a ligand dependent manner. Unlike PGC-1alpha, the interaction of PGC-1beta and the T3 receptor does not occur exclusively through the leucine-X-X-leucine-leucine motif in PGC-1beta. We have found that PGC-1beta is associated with the CPT-Ialpha gene in vivo. Overall, our results demonstrate that PGC-1beta is a coactivator in the T3 induction of CPT-Ialpha and that PGC-1beta has similarities and differences with the PGC-1alpha isoform. |
| Starting Page | 6 |
| Ending Page | 16 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.mce.2006.11.012 |
| PubMed reference number | 17239528 |
| Journal | Medline |
| Volume Number | 267 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0303720706005922 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0303720706005922?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.mce.2006.11.012 |
| Journal | Molecular and Cellular Endocrinology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
