NDLI: Associations between infiltrating lymphocyte subsets and hepatocellular carcinoma.

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Associations between infiltrating lymphocyte subsets and hepatocellular carcinoma.

Content Provider	Semantic Scholar
Author	Guo, Cang Yuan Yang, Hai-Chao Yang, Xiu-Hua Cheng, Wen Dong, Tian-Xiu Zhu, Wen-Jing Xu, Zheng Zhao, Liang
Copyright Year	2012
Abstract	AIMS We aimed to analyze the phenotype of tumor-infiltrating lymphocytes (TILs) and non-tumor infiltrating lymphocytes (NILs) in HCC and non-tumor tissues, and evaluate relationships between changes in these cells and the prognosis of HCC. METHODS Lymphocytes were isolated from HCC and corresponding non-tumor tissues and tested by flow cytometry. For comparison, clinical parameters were analyzed. RESULTS Compared with the non-tumor tissue, tumor tissue had a lower intensity of NK, NKT and CD8+T cell infiltration. TILs had higher intensity of CD4+CD25+Foxp3+regulatory T cell (Treg cells) infiltration compared with that in NILs. The prevalence of Treg cells was associated with fewer CD8 + T lymphocytes in the HCC immune microenvironment. The frequencies of NK cells and CD8+T cells in TILs of HCC patients with metastasis less than 12 months were lower than those without metastasis. However, the frequency of Treg cells was higher than those without metastasis. CONCLUSION These results suggest that the frequencies of CD8+T, NK and NKT cells as well as Treg cells in the tumor tissue of HCC are significantly associated with patient survival, and could be applied as predictive indicators for HCC prognosis.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.apjcpcontrol.org/paper_file/issue_abs/Volume13_No11/5909-13%209.5%20Cun-li%20Guo.pdf
Alternate Webpage(s)	http://ocean.kisti.re.kr/downfile/volume/apocp/POCPA9/2012/v13n11/POCPA9_2012_v13n11_5909.pdf
PubMed reference number	23317279v1
Volume Number	13
Issue Number	11
Journal	Asian Pacific journal of cancer prevention : APJCP
Language	English
Access Restriction	Open
Subject Keyword	Body tissue Flow Cytometry Forecast of outcome Helper-Inducer T-Lymphocyte Infiltration Leukemia, B-Cell Liver carcinoma Lymphocyte Subset Lymphocytes, Tumor-Infiltrating Natural Killer Cells Neoplasms Nephroblastoma Patients non-T, non-B, cALLa positive childhood acute lymphoblastic leukemia tumor tissue
Content Type	Text
Resource Type	Article

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