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Supplementary Information: Changes in ESCRT-III filament geometry drive membrane remodelling and fission in sillico
| Content Provider | Semantic Scholar |
|---|---|
| Copyright Year | 2019 |
| Abstract | We developed a minimal, coarse-grained, model of ESCRT-III based on general structural information gathered from in-vitro experiments [18, 27, 28, 29]. ESCRT-III filaments form membrane-adsorbed spirals, and our simulations start with a pre-assembled, tense spiral adsorbed onto a deformable membrane. We constructed the filament model based on three distinct general properties that are observed in all ESCRT-III filaments: strong internal bonds between sub-units, an attraction site to the membrane and an intrinsic chiral curvature. It is important to note that our model does not capture the fine structural details of monomers within the spiral. It only captures the global chiral structure of the filament as a whole. We used the structure in Ref. [29] to map the simulation length-scale (size and curvature of the filament) to the physical one observed in experiments. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://static-content.springer.com/esm/art:10.1186%2Fs12915-019-0700-2/MediaObjects/12915_2019_700_MOESM1_ESM.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
