Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

Content Provider	Semantic Scholar
Author	Lowe, David G. Capon, Daniel J. Delwart, Eric L. Sakaguchi, Alan Y. Goeddel, David Van Norman
Copyright Year	1987
Abstract	The human R-ras gene was isolated by low-stringency hybridization with a v-H-ras probe. The predicted 218 amino acid R-ras protein has an amino-terminal extension of 26 residues compared with H-ras p21, and shows 55% amino acid identity; conserved domains include the p21 GTP-binding site and the carboxy-terminal membrane localization sequence. R-ras has at least six exons, with the position of the first intron conserved relative to the Drosophila ras64B and Dictyostelium ras genes; there is no similarity in the exon-intron structure of the R-ras gene and of the mammalian H-, K-, and N-ras proto-oncogenes. Cloned mouse R-ras cDNAs exhibit 88% nucleotide and 94.5% predicted amino acid identity to human R-ras. Human R-ras was localized to chromosome 19, a site different from ras p21 genes. Mouse R-ras is syntenic with c-H-ras on chromosome 7.
Starting Page	137
Ending Page	146
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1016/0092-8674(87)90364-3
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0092867487903643
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0092867487903643?dgcid=api_sd_search-api-endpoint
PubMed reference number	3098437
Alternate Webpage(s)	https://doi.org/10.1016/0092-8674%2887%2990364-3
Journal	Medline
Volume Number	48
Journal	Cell
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article