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Efficacies of echinocandins versus azoles antifungal agents against Candida albicans and Candida dubliniensis isolates
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mohtady, Heba A. Nassar, Amani Samir, Nermin |
| Copyright Year | 2014 |
| Abstract | Background: Candida infection is a world wide problem with greatly changed epidemiology. Candida dubliniensis is an emerging non-albicans, shares several phenotypic and genotypic characteristics and closely related to Candida albicans. Fluconazole-resistant Candida spp. becomes a significant life-threatening problem especially in high risk patients. Echinocandins are promising antifungals with no recorded resistance. This study was done, first to differentiate C. dubliniensis from C. albicans by different phenotypic and molecular methods and to compare in vitro activities of echinocandins versus azoles against Candida spp. Subjects and Methods: One hundred fifty-seven oral and vaginal swabs collected from Dermatology Outpatients Clinic of Zagazig University Hospitals. Cultivation was done on Brilliance Candida agar. Growth at elevated temperature;t obacco agar VITECK2-YST and PCR were investigated. Antifungal susceptibility testing was done to C. albicans and C. dubliniensis to fluconazole and caspofungin by microdilution method. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://imed.pub/ojs/index.php/IAJAA/article/download/938/639 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
