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A subset of dynamic actin rearrangements in Drosophila requires the Arp2/3 complex
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cooley, Lynn |
| Copyright Year | 2002 |
| Abstract | The Arp2/3 complex has been shown to dramatically increase the slow spontaneous rate of actin filament nucleation in vitro, and it is known to be important for remodeling the actin cytoskeleton in vivo. We isolated and characterized loss of function mutations in genes encoding two subunits of the Drosophila Arp2/3 complex: Arpc1, which encodes the homologue of the p40 subunit, and Arp3, encoding one of the two actin-related proteins. We used these mutations to study how the Arp2/3 complex contributes to well-characterized actin structures in the ovary and the pupal epithelium. We found that the Arp2/3 complex is required for ring canal expansion during oogenesis but not for the formation of parallel actin bundles in nurse cell cytoplasm and bristle shaft cells. The requirement for Arp2/3 in ring canals indicates that the polymerization of actin filaments at the ring canal plasma membrane is important for driving ring canal growth. |
| Starting Page | 677 |
| Ending Page | 687 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 11854308v1 |
| Volume Number | 156 |
| Journal | The Journal of cell biology |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/24/78/0109065.PMC2174088.pdf |
| Alternate Webpage(s) | http://jcb.rupress.org/content/jcb/156/4/677.full.pdf |
| Alternate Webpage(s) | http://jcb.rupress.org/content/156/4/677.full.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cytoskeletal Filaments DNA Sequence Rearrangement Homologous Gene Microfilaments Mutation Oogenesis Ovary Plasma membrane Shaft Device Component Subgroup |
| Content Type | Text |
| Resource Type | Article |
