NDLI: Effects of 2-buten-4-olide, an endogenous satiety substance, on plasma glucose, corticosterone, and catecholamines.

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Effects of 2-buten-4-olide, an endogenous satiety substance, on plasma glucose, corticosterone, and catecholamines.

Content Provider	Semantic Scholar
Author	Matsumoto, Itsuro Oomura, Yutaka Nishino, Hitoo Nemoto, Satoru Aou, Shuji Aikawa, Tatsuya
Copyright Year	1994
Abstract	Effects of 2-buten-4-olide (2-B4O), an endogenous satiety substance, on levels of plasma glucose, corticosterone, and catecholamines were examined in fed, conscious, and unrestrained rats. A vascular indwelling catheter was inserted into the right atrium of the animal from the jugular vein 1 wk before the experiment. Injection of 2-B4O and blood sampling were performed through the catheter in an unanesthetized condition. The levels of plasma glucose, corticosterone, epinephrine, and norepinephrine increased significantly for 2 h after the start of intravenous injection of 2-B4O in a dose-dependent manner. The increases in glucose and catecholamines induced by 2-B4O injection were abolished by bilateral splanchnicotomy (SPX) but not by pretreatment with anti-corticotropin-releasing factor (CRF) antibody. The increase in corticosterone was abolished not by the SPX but by pretreatment with anti-CRF antibody. These findings suggest that 2-B4O, endogenously produced during food deprivation, may facilitate sympathoadrenal and hypothalamopituitary-adrenal functions through the central nervous system.
Starting Page	1
Ending Page	6
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.nagasaki-molphys.org/wp-content/uploads/2013/08/Matsumoto-Effects-of-2-buten-4-olide-an-endogenous-satiety-substance-on-plasma-glucose-corticosterone-and-catecholamines.pdf
PubMed reference number	8141398v1
Volume Number	266
Issue Number	2
Part	2
Journal	The American journal of physiology
Language	English
Access Restriction	Open
Subject Keyword	CNS disorder Catecholamines Corticosterone Corticotropin-Releasing Hormone Epinephrine Food deprivation (experimental) Glucose Gonadorelin Hematological Disease Norepinephrine Right atrial structure Satiation Structure of jugular vein butenolide
Content Type	Text
Resource Type	Article

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