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STRUCTURAL CHARACTERISTICS AND ANTIHYPERTENSIVE EFFECTS OF ANGIOTENSIN-I-CONVERTING ENZYME INHIBITORY PEPTIDES IN THE RENIN-ANGIOTENSIN AND KALLIKREIN KININ SYSTEMS
| Content Provider | Semantic Scholar |
|---|---|
| Author | Manoharan, Sivananthan Shuib, Adawiyah Suriza Binti Abdullah, Noorlidah |
| Copyright Year | 2017 |
| Abstract | BACKGROUND The commercially available synthetic angiotensin-I-converting enzyme (ACE) inhibitors are known to exert negative side effects which have driven many research groups globally to discover the novel ACE inhibitors. METHOD Literature search was performed within the PubMed, ScienceDirect.com and Google Scholar. RESULTS The presence of proline at the C-terminal tripeptide of ACE inhibitor can competitively inhibit the ACE activity. The effects of other amino acids are less studied leading to difficulties in predicting potent peptide sequences. The broad specificity of the enzyme may be due to the dual active sites observed on the somatic ACE. The inhibitors may not necessarily competitively inhibit the enzyme which explains why some reported inhibitors do not have the common ACE inhibitor characteristics. Finally, the in vivo assay has to be carried out before the peptides as the antihypertensive agents can be claimed. The peptides must be absorbed into circulation without being degraded, which will affect their bioavailability and potency. Thus, peptides with strong in vitro IC50 values do not necessarily have the same effect in vivo and vice versa. CONCLUSION The relationship between peptide amino acid sequence and inhibitory activity, in vivo studies of the active peptides and bioavailability must be studied before the peptides as antihypertensive agents can be claimed. |
| Starting Page | 383 |
| Ending Page | 406 |
| Page Count | 24 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://umexpert.um.edu.my/file/publication/00004379_154126_65448.pdf |
| PubMed reference number | 28573254v1 |
| Alternate Webpage(s) | https://doi.org/10.21010/ajtcam.v14i2.39 |
| DOI | 10.21010/ajtcam.v14i2.39 |
| Journal | African journal of traditional, complementary, and alternative medicines : AJTCAM |
| Volume Number | 14 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amino Acid Sequence Amino Acids Angiotensin-Converting Enzyme Inhibitors Angiotensins Antihypertensive Agents Blood Circulation Diploid Cell Dual Gastrointestinal Diseases Inhibitory Concentration 50 Kininogenase Kinins Nutraceuticals Pancreatin Patients Pepsin A Proline procollagen Type I N-terminal peptide |
| Content Type | Text |
| Resource Type | Article |
