NDLI: Electrical heterogeneity, cardiac arrhythmias, and the sodium channel.

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Electrical heterogeneity, cardiac arrhythmias, and the sodium channel.

Content Provider	Semantic Scholar
Author	Antzelevitch, Charles
Copyright Year	2000
Abstract	I t was not long ago that we thought of the ventricles of the heart as being composed of 2 basic cell types: specialized conducting cells that make up the His-Purkinje system and ventricular myocytes. Studies conducted over the last decade have highlighted the diversity among the cells that comprise the ventricular myocardium, pointing to regional differences in the electrical properties of cells as well as major distinctions in the response to pharmacological agents and pathophysiological states. 1,2 Several interesting differences have been described between endocardium and epicardium, and a unique population of cells located in the midmyocardial layers has been identified and shown to display electrophysiological and pharmacological profiles different from those of epicardium and endocardium. These cells, known as M cells, have been observed in canine, guinea pig, rabbit, pig, and human ventricles. 3–8
Starting Page	053902
Ending Page	053902
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/87/11/964.full.pdf
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/87/11/964.full.pdf?download=true
PubMed reference number	11090538v1
Volume Number	87
Issue Number	11
Journal	Circulation research
Language	English
Access Restriction	Open
Subject Keyword	Artificial cardiac pacemaker Behavior Cavia porcellus Cerebral Ventricles Endocardium Epicardium Heart Ventricle Muscle Cells Myocardium Pharmacology Sodium Channel anatomical layer
Content Type	Text
Resource Type	Article

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