NDLI: Lack of association of vitamin D receptor BsmI gene polymorphism with bone mineral density in Spanish postmenopausal women

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Lack of association of vitamin D receptor BsmI gene polymorphism with bone mineral density in Spanish postmenopausal women

Content Provider	Semantic Scholar
Author	Moran, Jose M. Pedrera-Canal, María Rodriguez-Velasco, Francisco J. Vera, Vicente Lavado-García, Jesús Mª Fernández, Pilar Pedrera-Zamorano, Juan Diego
Copyright Year	2015
Abstract	Osteoporosis is a polygenic disorder that is determined by the effects of several genes, each with relatively modest effects on bone mass. The aim of this study was to determine whether the vitamin D receptor single nucleotide polymorphism BsmI is associated with bone mineral density (BMD) in Spanish postmenopausal women. A total of 210 unrelated healthy postmenopausal women aged 60 ± 8 years were genotyped using TaqMan(®) SNP Genotyping Assays. Lumbar and femoral BMD were determined by dual-energy X-ray absorptiometry (DEXA). Daily calcium and vitamin D intake were determined by a food questionnaire. No differences were found in the femoral neck, trochanter, Ward's Triangle, L2, L3, L4, L2-L4, or between the femoral neck and total hip BMD after further adjustment for potential confounding factors (P > 0.05) (age, BMI, years since menopause and daily calcium intake). The BsmI polymorphism in the VDR gene was not associated with BMD in Spanish postmenopausal women.
File Format	PDF HTM / HTML
DOI	10.7717/peerj.953
PubMed reference number	26157644
Journal	Medline
Volume Number	3
Alternate Webpage(s)	https://peerj.com/articles/953.pdf
Alternate Webpage(s)	http://dehesa.unex.es/bitstream/handle/10662/5650/peerj_953.pdf?isAllowed=y&sequence=1
Alternate Webpage(s)	https://doi.org/10.7717/peerj.953
Journal	PeerJ
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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