NDLI: Design and evaluation of solid self-emulsifying drug delivery system of rosuvastatin calcium

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Design and evaluation of solid self-emulsifying drug delivery system of rosuvastatin calcium

Content Provider	Semantic Scholar
Author	Rokad, Vipul Nagda, Chirag D. Nagda, Dhruti C.
Copyright Year	2014
Abstract	Background: The work has been undertaken with an objective to prepare a self-emulsifying drug delivery system (SEDDS) of rosuvastatin calcium (ROS) with the least amount of surfactant which could enhance its solubility and oral bioavailability. Materials and Methods: Spectrophotometric method was used to estimate the solubility of the drug in various oils, surfactant and co-surfactant. The phase behavior and most efficient self-emulsifying region were identified by constructing pseudo ternary phase diagram. The solid-SEDDS (S-SEDDS) was prepared using an adsorbent consequently the prepared S-SEDDS were filled up in hard gelatin capsule which were evaluated for various physicochemical parameters. Results: The composition of optimized formulation consisted of 10 mg of ROS, capmul MCM (oil), cremophor ELP (surfactant) and propylene glycol (co-surfactant). The optimized formulation showed negative zeta potential (−22.11 mv), optimal particle size (10.59 nm) and demonstrated excellent self-emulsifying ability with a maximum solubilizing capability. The S-SEDDS formulations were prepared from the optimized liquid SEDDS, which revealed maximum release rate (97.7%) among all the prepared S-SEDDS formulation and marketed formulation. Conclusion: It was concluded that S-SEDDS prepared from liquid SEDDS can be a promising novel approach to enhance the solubility and drug release of ROS, which in turn also develops a stable formulation, least drugs leakage and precipitation than the liquid SEDDS. Key words: Adsorbent, bioavailability, drug release, rosuvastatin calcium, self-emulsifying drug delivery system, solubility
Starting Page	37
Ending Page	46
Page Count	10
File Format	PDF HTM / HTML
DOI	10.5530/jyp.2014.3.7
Volume Number	6
Alternate Webpage(s)	http://www.jyoungpharm.org/sites/default/files/JYP_6_3_2014_7.pdf
Alternate Webpage(s)	https://doi.org/10.5530/jyp.2014.3.7
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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