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Vasopressin and oxytocin modulation of melatonin secretion from rat pineal glands
| Content Provider | Semantic Scholar |
|---|---|
| Author | Simonneaux, Valérie Ouichou, Ali Burbach, J. Peter H. Pevet, Paul |
| Copyright Year | 1990 |
| Abstract | The rat pineal gland is known to release melatonin in response to noradrenergic stimulation. Since vasopressin (VP)- and oxytocin (OT)-containing fibers innervate the pineal gland, the effects of VP and OT on melatonin release from perifused rat pineal glands were investigated. VP (10(-7) M) and OT (10(-6) M) decreased the basal melatonin secretion. No dose-dependent effect was observed. At high concentrations (10(-5)) these peptides potentiated the isoproterenol-induced increase of melatonin secretion. Below 10(-5) M no potentiation was observed. Fragments of VP ([pGlu4,Cys6]VP(4-9] and OT (pGlu4,Cys6]OT(4-9] did not display any effect on the isoproterenol-induced melatonin secretion. |
| Starting Page | 1075 |
| Ending Page | 1079 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0196-9781(90)90133-P |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/019697819090133P |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/019697819090133P?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 2087432 |
| Alternate Webpage(s) | https://doi.org/10.1016/0196-9781%2890%2990133-P |
| Journal | Medline |
| Volume Number | 11 |
| Journal | Peptides |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
