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Synthesis and biological screening of certain new triazole schiff bases and their derivatives bearing substituted benzothiazole moiety
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chandramouli Shivanand, M. R. Nayanbhai, Thakar Bhaumik Bheemachari Udupi, Rajgopal H. |
| Copyright Year | 2012 |
| Abstract | 3-Substituted-4-amino-5-mercapto-1, 2, 4-triazole ( 3) was obtained in an excellent yield in a single st p by the condensation of a well known drug norfloxacin havin g free carboxyl group ( 1) with thiocarbohydrazide ( 2). Various 3-Substituted-4-amino-5-mercapto-1, 2, 4-triazoloSc hiff bases ( 4a1-a11) have been synthesized by the condensation of the mercapto triazole ( 3) with different aromatic aldehydes. The triazolo S chiff bases ( 4a1-a11) on heating with 2-Amino-7-chloro-6-fluorobenzothiazole in equimolar proportions yielded the required 3-Substitued-5-(2 '-imino-7chloro-6-fluorobenzothiazolyl) 1, 2, 4-triazolo Sch iff bases ( 5a1-a11). The structures of newly synthesized compounds have been established on the basis of the ir sp ctral data and elemental analysis. Some selec t d compounds were screened for analgesic and anti-infl ammatory activity. Some of the compounds exhibited encouraging results. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jocpr.com/articles/synthesis-and-biological-screening-of-certain-new-triazole-schiff-bases-and-their-derivatives-bearing-substituted-benzot.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
