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Development and Multi-laboratory Verification of US EPA Method 543 for the Analysis of Drinking Water Contaminants by Online Solid Phase Extraction-LC-MS-MS.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shoemaker, Jody A. |
| Copyright Year | 2016 |
| Abstract | A drinking water method for seven pesticides and pesticide degradates is presented that addresses the occurrence monitoring needs of the US Environmental Protection Agency (EPA) for a future Unregulated Contaminant Monitoring Regulation (UCMR). The method employs online solid phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS-MS). Online SPE-LC-MS-MS has the potential to offer cost-effective, faster, more sensitive and more rugged methods than the traditional offline SPE approach due to complete automation of the SPE process, as well as seamless integration with the LC-MS-MS system. The method uses 2-chloroacetamide, ascorbic acid and Trizma to preserve the drinking water samples for up to 28 days. The mean recoveries in drinking water (from a surface water source) fortified with method analytes are 87.1-112% with relative standard deviations of <14%. Single laboratory lowest concentration minimum reporting levels of 0.27-1.7 ng/L are demonstrated with this methodology. Multi-laboratory data are presented that demonstrate method ruggedness and transferability. The final method meets all of the EPA's UCMR survey requirements for sample collection and storage, precision, accuracy, and sensitivity. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/C3AY41242C |
| Alternate Webpage(s) | https://watermark.silverchair.com/bmw098.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAkwwggJIBgkqhkiG9w0BBwagggI5MIICNQIBADCCAi4GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMGKGcFs1wYZkQowNJAgEQgIIB_13XHeVkYm3a11oxjJ0PzDc6GtNB9UIjK9DyDc9GU4p9gd63oJWzp2CDpcHAJgdv8Y_F2S2FZ6miukYRcUkQfb8lOovSU1Jl_o1Dp0XAlAtdsmRWUDEBQ8gU3UWCZ_42oqfBqBEk5tNVuyCimYxvyK_BbV_ABW2CbxuOX2kcGCUpqBax23QKwlhMebFDXQy5kz6ObBDxLpcEJE-aKSxaFea4s6TPXLWhuGURydIZy0pVT7i35X7M5xhFJ-KaZWuHqcKWtCwmooJXrixp2eQTrSwM4glZG6LC9EskUkgY-jWcGCfDZ00eSikKKU7Oc_1UCPkLq5H9Wu9xEIz4FJs7dRgz6YOUZVWuHxmCf1ahzSZASixvjuC_4QXKuI-2j9N63S0rePsGEbWOK6BybLDXEKwVg_5RTEJIXe3e4lvdL-Oe_w0p_xr0iL1jTNwb_v0g07Z7JdQ-LzvdUja8JpojCHjn-95RSOFkrKDJIR6pEepwVKf8sh8ti1isuCmNbB1Uj66Zsxf_j8YgnnvRyULWNW-9ywlckrbA8y1Q5IE1-YRUA387byAS3swKBPJaom4wiaCmshwNVpbZlRl-ZKxSp9cskKozXujbjiV0jMVU9jUEWnlx7WoCinlucTX5uSIRD974U4r_FXwrTrG1Av24yIgmIZnOkcIn9CUf1oc8k9I |
| PubMed reference number | 27353349 |
| Alternate Webpage(s) | https://doi.org/10.1039/C3AY41242C |
| Journal | Medline |
| Journal | Journal of chromatographic science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |