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Mycophenolate mofetil in children with steroid-dependent and/or frequently relapsing nephrotic syndrome
| Content Provider | Semantic Scholar |
|---|---|
| Author | Al-Akash, Samhar I. Makdama, Abdulkarim Al |
| Copyright Year | 2005 |
| Abstract | BACKGROUND Mycophenolate mofetil (MMF) has emerged as a new agent for treatment of a variety of glomerular diseases. This study examines the safety and efficacy of MMF in treating pediatric patients with steroid-dependent (SD) and/or frequently relapsing (FR) nephrotic syndrome (NS). METHODS We retrospectively reviewed the medical records of 18 patients with SDNS and/or FRNS treated with MMF for at least 3 months. MMF was used in 11 patients with SDNS (n=10) and FRNS (n=1), including 7 males and 4 females. RESULTS Mean age at time of diagnosis of NS was 3.3 years (range, 1.1-8.5 years), and at the start of MMF 5.9 years (range, 2.9-10 years). Seven patients had a renal biopsy prior to starting MMF; all had mesangial proliferative glomerulonephritis. Mean follow-up after starting MMF was 12.2 months (range, 4-24 months). Mean MMF dose was 948 mg/m2/day (range, 500-1087 mg/m2/day). MMF resulted in improvement in 9 of 11 patients, with 8 patients weaned off steroids completely, with a reduction in the mean relapse rate from 4.7 relapses/patient/year (range, 2.4-6) before MMF to 1.05 relapses/patient/year (range, 0-4.5) after MMF therapy (P=0.0001). The relative risk for relapse before MMF was 4.7 (P=0.0002). None of the patients had significant adverse events or intolerance to MMFtherapy. CONCLUSION We conclude that MMF is a safe and effective option for treatment of children with SDNS and/or FRNS. |
| Starting Page | 380 |
| Ending Page | 384 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.5144/0256-4947.2005.380 |
| PubMed reference number | 16270759 |
| Journal | Medline |
| Volume Number | 25 |
| Alternate Webpage(s) | https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/94/fd/asm-5-380.PMC6089728.pdf |
| Alternate Webpage(s) | https://doi.org/10.5144/0256-4947.2005.380 |
| Journal | Annals of Saudi medicine |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
