NDLI: Delta Vs Gamma Auditory Steady State Synchrony in Schizophrenia.

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Delta Vs Gamma Auditory Steady State Synchrony in Schizophrenia.

Content Provider	Semantic Scholar
Author	Puvvada, Krishna Chaitanya Summerfelt, Ann T. Du, Xiaoming Krishna, Nithin Kochunov, Peter V. Rowland, Laura Simon, Jonathan Z. Elliot, L.
Copyright Year	2018
Abstract	Background Delta band (1-4 Hz) neuronal responses support the precision and stability of auditory processing, and a deficit in delta band synchrony may be relevant to auditory domain symptoms in schizophrenia patients. Methods Delta band synchronization elicited by a 2.5 Hz auditory steady state response (ASSR) paradigm, along with those from theta (5 Hz), alpha (10 Hz), beta (20 Hz), gamma (40 Hz), and high gamma (80 Hz) frequency ASSR, were compared in 128 patients with schizophrenia, 108 healthy controls, and 55 first-degree relatives (FDR) of patients. Results Delta band synchronization was significantly impaired in patients compared with controls (F = 18.3, P < .001). There was a significant 2.5 Hz by 40 Hz ASSR interaction (P = .023), arising from a greater reduction of 2.5 Hz ASSR than of 40 Hz ASSR, in patients compared with controls. Greater deficit in delta ASSR was associated with auditory perceptual abnormality (P = .007) and reduced verbal working memory (P < .001). Gamma frequency ASSR impairment was also significant but more modest (F = 8.7, P = .004), and this deficit was also present in FDR (P = .022). Conclusions The ability to sustain delta band oscillation entrainment in the auditory pathway is significantly reduced in schizophrenia patients and appears to be clinically relevant.
Starting Page	378
Ending Page	387
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.isr.umd.edu/Labs/CSSL/simonlab/pubs/PuvvadaEtAlSchizBull2017.pdf
PubMed reference number	29036430v1
Alternate Webpage(s)	https://doi.org/10.1093/schbul/sbx078
DOI	10.1093/schbul/sbx078
Journal	Schizophrenia bulletin
Volume Number	44
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	Acoustic Evoked Brain Stem Potentials Auditory pathway structure Eighty False Discovery Rate Hearing problem Hertz (Hz) Interferon Type II Memory Disorders Patients Schizophrenia hearing impairment
Content Type	Text
Resource Type	Article

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