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Platelet-activating factor causes ventilation-perfusion mismatch in humans.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rodríguez-Roisín, Roberto Felez, Miquel A. Chung, Kian Fan Barberà, Joan Albert Wagner, Peter D. Cobos, A. Muñoz Barnes, Peter J. Roca, Josep |
| Copyright Year | 1994 |
| Abstract | We hypothesized that platelet-activating factor (PAF), a potent inflammatory mediator, could induce gas exchange abnormalities in normal humans. To this end, the effect of aerosolized PAF (2 mg/ml solution; 24 micrograms) on ventilation-perfusion (VA/Q) relationships, hemodynamics, and resistance of the respiratory system was studied in 14 healthy, nonatopic, and nonsmoking individuals (23 +/- 1 [SEM]yr) before and at 2, 4, 6, 8, 15, and 45 min after inhalation, and compared to that of inhaled lyso-PAF in 10 other healthy individuals (24 +/- 2 yr). PAF induced, compared to lyso-PAF, immediate leukopenia (P < 0.001) followed by a rebound leukocytosis (P < 0.002), increased minute ventilation (P < 0.05) and resistance of the respiratory system (P < 0.01), and decreased systemic arterial pressure (P < 0.05). Similarly, compared to lyso-PAF, PaO2 showed a trend to fall (by 12.2 +/- 4.3 mmHg, mean +/- SEM maximum change from baseline), and arterial-alveolar O2 gradient increased (by 16.7 +/- 4.3 mmHg) (P < 0.02) after PAF, because of VA/Q mismatch: the dispersion of pulmonary blood flow and that of ventilation increased by 0.45 +/- 0.1 (P < 0.01) and 0.29 +/- 0.1 (P < 0.04), respectively. We conclude that in normal subjects, inhaled PAF results in considerable immediate VA/Q inequality and gas exchange impairment. These results reinforce the notion that PAF may play a major role as a mediator of inflammation in the human lung. |
| Starting Page | 311 |
| Ending Page | 318 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://diposit.ub.edu/dspace/bitstream/2445/8262/1/527894.pdf |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/116000/116944/JCI94116944.pdf |
| PubMed reference number | 8282786v1 |
| Volume Number | 93 |
| Issue Number | 1 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Blood Platelets Congenital Abnormality Flatulence Inspiration function Leukocytosis Leukopenia Mediator brand of benfluorex hydrochloride Oxygen measurement, partial pressure, arterial Platelet Activating Factor Respiration Structure of parenchyma of lung efmoroctocog alfa 1 UNT Injection torr |
| Content Type | Text |
| Resource Type | Article |
