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Vascular endothelial growth factor receptor-1 signaling promotes mobilization of macrophage lineage cells from bone marrow and stimulates solid tumor growth.

Content Provider	Semantic Scholar
Author	Muramatsu, Masashi Yamamoto, Seiji P. Osawa, Tsuyoshi Shibuya, Masahiro
Copyright Year	2010
Abstract	Vascular endothelial growth factor and its receptors, including Flt-1 and Flk-1, are involved in angiogenesis under physiologic and pathologic conditions. Recently, Flt-1-expressing cells were reported to contribute to the intracranial growth of glioma cells. However, the role of Flt-1 signaling in solid tumor growth in s.c. tissue has not been elucidated. To investigate how Flt-1 signaling is involved in the proliferation of solid tumors, we implanted tumor cells into wild-type (Wt) and Flt-1 tyrosine kinase (TK)-deficient (Flt-1 TK(-/-)) mice. Growth of HSML and B16 but not Lewis lung carcinoma cell in s.c. tissue was significantly decreased in Flt-1 TK(-/-) mice. Angiogenesis in HSML and B16 tumors was remarkably reduced in Flt-1 TK(-/-) mice. Moreover, the infiltration of macrophage lineage cells into HSML and B16 tumors was clearly suppressed in Flt-1 TK(-/-) mice. Pericyte marker(+) cells were also reduced in Flt-1 TK(-/-) mice. However, in the border area of tumor, angiogenesis and the infiltration of macrophage lineage cell were basically similar between Wt and Flt-1 TK(-/-) mice. In bone marrow (BM) transplantation experiments, tumor angiogenesis, infiltration of macrophage lineage cells, and tumor growth were significantly suppressed in Wt/Flt-1 TK(-/-) mice implanted with Flt-1 TK(-/-) BM cells compared with those implanted with Wt BM cells. We conclude that Flt-1 signaling is involved in the function of BM-derived cell, such as the migration of macrophages into cancerous tissues, and significantly contributes to angiogenesis and tumor progression.
Starting Page	2
Ending Page	5
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/canres/70/20/8211.full.pdf
PubMed reference number	20924106v1
Alternate Webpage(s)	https://doi.org/10.1158/0008-5472.CAN-10-0202
DOI	10.1158/0008-5472.can-10-0202
Journal	Cancer research
Volume Number	70
Issue Number	20
Language	English
Access Restriction	Open
Subject Keyword	Body tissue Bone Marrow Carcinoma of lung Endothelial Growth Factors Glioma Implants Non-Small Cell Lung Carcinoma Pericytes Pituitary Neoplasms Protein Tyrosine Kinase Tumor Angiogenesis Tumor Progression Vascular Endothelial Growth Factor Receptor 2, human Vascular Endothelial Growth Factor Receptor-1 solid tumor
Content Type	Text
Resource Type	Article

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