Structural aspects of AMPA receptor activation, desensitization and deactivation

Content Provider	Semantic Scholar
Author	Hansen, Kasper B. Yuan, Hongjie Traynelis, Stephen F.
Copyright Year	2007
Abstract	Glutamate mediates most of the excitatory neurotransmission in the mammalian central nervous system by activating ionotropic glutamate receptors. Structural and functional studies of ionotropic glutamate receptors have offered detailed insight into the mechanism by which these integral membrane proteins function. In particular, advances in our understanding of the atomic structure of the agonist-binding domain have provided new opportunities to consider the conformational changes that take place in a functioning ligand-gated ion channel. Several recent studies have turned up important new ideas about the structural determinants of channel activation, deactivation and desensitization of AMPA receptors. Working hypotheses derived from this structural insight offer a rare opportunity to enrich and guide functional studies.
Starting Page	281
Ending Page	288
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1016/j.conb.2007.03.014
PubMed reference number	17419047
Journal	Medline
Volume Number	17
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0959438807000463
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0959438807000463?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	http://www.pharm.emory.edu/straynelis/Papers/2007/Hansen_et_al_Curr_Opin_Neurobiol_2007.pdf
Alternate Webpage(s)	https://doi.org/10.1016/j.conb.2007.03.014
Journal	Current Opinion in Neurobiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article