NDLI: Dynamic Kinetic Resolution of α-Bromo Carboxylic Acid Derivatives in Asymmetric Nucleophilic Substitution with Chiral α-Amino Esters

Content Provider	Semantic Scholar
Author	Chang, Ji-Yeon Shin, Eun-Kyoung Kim, Yongtae Park, Yong Sun
Copyright Year	2005
Abstract	Dynamic kinetic resolution of -bromo carboxylic acid derivatives in nucleophilic substitution with chiral -amino ester nucleophiles in the presence of TBAI and DIEA has been investigated for stereoselective syntheses of 1,1'-iminodicarboxylic acid derivatives. Nucleophilic substitutions with various chiral -amino esters gave iminodiacetates 2-8 with stereoselectivities up to 87 : 13 dr. Also, the reactions of N-(-bromo--phenylacetyl)-L-alanine methyl ester with L-alanine, D-alanine and glycine methyl ester nucleophiles afforded N-carboxyalkyl dipeptide analogues 10-12 up to 90 : 10 dr.�⨀ԀĀ衺�⨀ԀĀऐ돀졽�⨀堘�⨀ꢐ�⨀돐좐�⨀��⨀킐�⨀뤏덐�⨀렏頏࢑�⨀਀࢑�⨀ᢑ�⨀؀ကᢑ�⨀?麆Ѐက䂑�⨀䂑�⨀
Starting Page	989
Ending Page	992
Page Count	4
File Format	PDF HTM / HTML
DOI	10.5012/bkcs.2005.26.6.989
Volume Number	26
Alternate Webpage(s)	http://pdf.easechem.com/pdf/32/a9a8238e-8a31-4f0e-a380-1e90aceb5269.pdf
Alternate Webpage(s)	https://doi.org/10.5012/bkcs.2005.26.6.989
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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