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Formulation and Evaluation of Maltodextrin based Proniosomal Drug Delivery System containing Anti-diabetic (Glipizide) drug
| Content Provider | Semantic Scholar |
|---|---|
| Author | Raja, K. Palu, Jestin |
| Copyright Year | 2003 |
| Abstract | Glipizide loaded maltodextrin based proniosome were prepared by slurry method with different surfactant to cholesterol ratio. The proniosome formulations were evaluated for FT-IR study, angle of repose and scanning electron microscopy. The niosomal suspensions were further evaluated for entrapment efficiency, In-vitro release study, Kinetic data analysis, Stability study, In-vivo hypoglycemic Study. The result from SEM analyses has confirmed the coating of surfactant on the surface of carrier. The formulation F4 which showed higher entrapment efficiency of 84.25 ± 1.25 and in-vitro release of 99.23% at the end of 24hr was found to be best among the all 7 formulation. Release was best explained by the zero order kinetics. Kinetic analysis shows that the drug release follows super case II transport diffusion. Proniosome formulation has showed appropriate stability for 90 days when compared with reconstituted niosomes by storing the formulation at refrigerator condition. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(PT=78)%20pp%20471-477.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
