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Caractérisation des dangers des contaminants alimentaires : ce qui change; conséquences pour la recherche et l’évaluation
| Content Provider | Semantic Scholar |
|---|---|
| Author | Cravédi, Jean-Pierre Jourdan, Fabien |
| Copyright Year | 2019 |
| Abstract | Despite major advances in molecular and cellular biology, systems biology and bioinformatics, toxicology applied to the risk assessment of chemicals and toxins has not changed significantly during the last decades. A radical conceptual and methodological change must emerge if a large number of chemicals or their combinations in mixtures need to be tested at a lower cost and quickly. The development and implementation of in vitro tools, recommended by international regulatory authorities, are essential steps in these changes. Toxicologists must now rely on the potential of systems biology, multiomics data integration and public databases to bridge the gap between initial molecular events and adverse effects at the level of a biological system and then an individual. In addition to proteomics and transcriptomics data capable of informing about potential changes in cell function and infrastructure, metabolomics approaches provide information about metabolite levels or flows of metabolites altered by toxic substances and can guide the selection of specific and sensitive early biomarkers for the subsequent development of high throughput screening. The analysis of big data and their modelling should make it possible to better predict the links between exposure to toxic substances and physiopathological conditions. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://inra-dam-front-resources-cdn.brainsonic.com/ressources/afile/459993-87c6a-resource-presentation-jp-cravedi.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
