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Potentiation of rabbit trigeminal responses to capsaicin in a low pH environment
| Content Provider | Semantic Scholar |
|---|---|
| Author | Martenson, Melissa E. Ingram, Susan L. Baumann, Thomas K. |
| Copyright Year | 1994 |
| Abstract | The sensitivity of 35 adult rabbit trigeminal ganglion neurons to low pH (pH 6.0), 10 microM capsaicin (CAP) and 10 microM capsaicin at low pH (CAP@pH6.0) was studied using voltage-clamp whole-cell recording techniques. Neurons responded to pH 6.0 with a transient inward current, followed by a more slowly activating (sustained) net inward current. Responses to capsaicin showed only a sustained current. Capsaicin caused an increase in membrane conductance, whereas responses to low pH were associated with either a net increase or decrease in conductance. A subset of neurons (n = 14) responded to CAP@pH6.0 with a sustained current which exceeded the sum of the peak sustained currents evoked by CAP and pH 6.0 applied singularly by approximately a factor of 4. The current was associated with a substantial increase in membrane conductance. The present results indicate that, in addition to a direct conductance activating effect, protons have the ability to enhance the current evoked by capsaicin. |
| Starting Page | 143 |
| Ending Page | 147 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0006-8993(94)90690-4 |
| PubMed reference number | 7922561 |
| Journal | Medline |
| Volume Number | 651 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0006899394906904 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0006899394906904?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0006-8993%2894%2990690-4 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
