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Anti-oxidant and cytotoxic activity of Cajanus cajan ( L ) Millsp alkaline extracts
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rerk-Am, Ubon Laovitthayanggoona, Sarunya Kongsombata, Bantika Tangsatirapakdeea, Sinn Banchonglikitkula, Chuleratana Klong, Tambon Luang, Amphoe Klong |
| Copyright Year | 2015 |
| Abstract | Pigeon pea (Cajanus cajan (L) Millsp) is among the dry leguminous seed. Pigeon pea has high levels of proteins and important amino acids such as methionine, lysine and tryptophan. The present study was performed to evaluate antioxidant and cytotoxic activity of the alkaline extracts from Pigeon pea. The antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazin (DPPH) radical scavenging assay and lipid peroxidation ( carotene bleaching model). The EC50 value was 61.39 μg/ml and 45.37 μg/ml, respectively. The cytotoxicity (IC50) was determined using MTT assay. The ATCC CRL-1474, dermal human fibroblast was treated with alkaline extracts at 1000, 500, 250, 125, 62.50, 31.25, 15.63, and 7.81 μg/ml. for 24 h. The IC50 value was more than 1000 μg/ml. The results showed that the alkaline extracted have high potential in antioxidant activity and non toxic to human skin. It would be interesting to do further study as anti-wrinkle agents. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.thaiscience.info/Article%20for%20ThaiScience/Article/2/10031491.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
