NDLI: Gemigliptin: An Update of Its Clinical Use in the Management of Type 2 Diabetes Mellitus

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Gemigliptin: An Update of Its Clinical Use in the Management of Type 2 Diabetes Mellitus

Content Provider	Semantic Scholar
Author	Kim, Sung-Ho Yoo, Jung-Hwa Park, Cheol Young
Copyright Year	2016
Abstract	Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of oral antidiabetic agent for the treatment of type 2 diabetes mellitus. They increase endogenous levels of incretin hormones, which stimulate glucose-dependent insulin secretion, decrease glucagon secretion, and contribute to reducing postprandial hyperglycemia. Although DPP-4 inhibitors have similar benefits, they can be differentiated in terms of their chemical structure, pharmacology, efficacy and safety profiles, and clinical considerations. Gemigliptin (brand name: Zemiglo), developed by LG Life Sciences, is a potent, selective, competitive, and long acting DPP-4 inhibitor. Various studies have shown that gemigliptin is an optimized DPP-4 inhibitor in terms of efficacy, safety, and patient compliance for treatment of type 2 diabetes mellitus. In this review, we summarize the characteristics of gemigliptin and discuss its potential benefits in clinical practice.
Starting Page	339
Ending Page	353
Page Count	15
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-40-339.pdf
Alternate Webpage(s)	https://www.e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-40-e29.pdf
PubMed reference number	27766241v1
Volume Number	40
Journal	Diabetes & metabolism journal
Language	English
Access Restriction	Open
Subject Keyword	Antidiabetics Chemical Structure Compliance behavior Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Dipeptidyl Peptidase-4 Inhibitor Dipeptidyl-Peptidase IV Glucose Hyperglycemia Incretins Pharmacology Proprietary Name benefit gemigliptin glucagon secretion insulin secretion
Content Type	Text
Resource Type	Article

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