NDLI: Exercise-induced attenuation of treatment side-effects in newly diagnosed prostate cancer patients beginning androgen deprivation therapy: a randomised controlled trial.

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Exercise-induced attenuation of treatment side-effects in newly diagnosed prostate cancer patients beginning androgen deprivation therapy: a randomised controlled trial.

Content Provider	Semantic Scholar
Author	Ndjavera, W. Orange, Samuel T. Doherty, Alasdair F. O’ Leicht, A. S. Rochester, Mark A. Mills, Robert D. Saxton, J. M.
Copyright Year	2019
Abstract	OBJECTIVES 1) To assess whether exercise training attenuates the adverse effects of treatment in newly diagnosed prostate cancer patients beginning androgen deprivation therapy (ADT), and 2) to examine whether exercise-induced improvements are sustained after the withdrawal of supervised exercise. PATIENTS AND METHODS Fifty prostate cancer patients scheduled for ADT were randomised to an exercise group (n = 24) or a control group (n = 26). The exercise group completed 3-months of supervised aerobic and resistance exercise training (2x/week for 60 min), followed by 3-months of self-directed exercise. Outcomes were assessed at baseline, 3-months, and 6-months. The primary outcome was difference in fat mass at 3-months. Secondary outcomes included fat-free mass, cardiopulmonary exercise testing variables, QRISK2 score, anthropometry, blood-borne biomarkers, fatigue, and quality of life (QoL). RESULTS At 3-months, exercise training prevented adverse changes in peak oxygen uptake (1.9 ml.kg-1 .min-1 , p = 0.038), ventilatory threshold (1.7 ml.kg-1 .min-1 , p = 0.013), oxygen uptake efficiency slope (0.21, p = 0.005) and fatigue (4.5, p = 0.024) compared with controls. After the supervised exercise was withdrawn, the differences in cardiopulmonary fitness and fatigue were not sustained, but the exercise group showed significantly higher QoL (8.5, p = 0.034) and a reduced QRISK2 score (-2.9%, p = 0.041) compared to controls. CONCLUSION A short-term programme of supervised exercise for prostate cancer patients beginning ADT results in sustained improvements in QoL and cardiovascular event risk profile.
File Format	PDF HTM / HTML
DOI	10.1111/bju.14922
PubMed reference number	31605663
Journal	Medline
Alternate Webpage(s)	http://nrl.northumbria.ac.uk/40973/2/PROSCARDIO_submitted_v1.pdf
Alternate Webpage(s)	https://doi.org/10.1111/bju.14922
Journal	BJU international
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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