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Insomnia with objective short sleep duration and incident hypertension: the Penn State Cohort.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fernandez-Mendoza, Julio Vgontzas, Alexandros N. Liao, Duanping Shaffer, Michele L. Vela-Bueno, Antonio Basta, Maria Bixler, Edward Oren |
| Copyright Year | 2012 |
| Abstract | Insomnia with objective short sleep duration appears to be a biologically more severe phenotype of the disorder. No longitudinal study to date has examined the association of this type of insomnia with incident hypertension using polysomnography. From a random, general population sample of 1741 adults of the Penn State Cohort, 1395 were followed-up after 7.5 years, and 786 did not have hypertension at baseline. Hypertension was determined by a self-report of receiving treatment for high blood pressure. Chronic insomnia was defined as a complaint of insomnia lasting ≥1 year, whereas poor sleep was defined as moderate-to-severe sleep difficulties. All of the subjects underwent 8-hour polysomnography. Sleep-disordered breathing (SDB) was defined as an obstructive apnea/hypopnea index≥5. We used the median polysomnographic percentage of sleep time to define short sleep duration (ie, <6 hours). We controlled for sex, race, age, caffeine, cigarettes and alcohol consumption, depression, sleep-disordered breathing, diabetes mellitus, obesity, and blood pressure in our analyses. Compared with normal sleepers who slept≥6 hours, the highest risk for incident hypertension was in chronic insomniacs with short sleep duration (odds ratio, 3.8 [95% CI, 1.6-9.0]). The risk for incident hypertension in poor sleepers with short sleep duration was significantly increased but became marginally significant after controlling for obesity (odds ratio, 1.6 [95% CI, 0.9-2.8]). Chronic insomnia with short sleep duration is associated with an increased risk for incident hypertension in a degree comparable to sleep-disordered breathing. Objective short sleep duration in insomnia may serve as a useful predictor of the biological severity of the disorder. |
| Starting Page | 1772 |
| Ending Page | 1773 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/60/4/929.full.pdf?download=true |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/early/2012/08/14/HYPERTENSIONAHA.112.193268.full.pdf?download=true |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/60/4/929.full.pdf |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/early/2012/08/14/HYPERTENSIONAHA.112.193268.full.pdf |
| PubMed reference number | 22892811v1 |
| Alternate Webpage(s) | https://doi.org/10.1161/HYPERTENSIONAHA.112.193268 |
| DOI | 10.1161/hypertensionaha.112.193268 |
| Journal | Hypertension |
| Volume Number | 60 |
| Issue Number | 4 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alcohol consumption Caffeine Chronic Insomnia Cigarette Depressive disorder Diabetes Mellitus Ethanol Hypertensive disease Odds Ratio Sleep Apnea Syndromes Sleep Apnea, Central Sleep Apnea, Obstructive Sleeplessness proteasome storage granule |
| Content Type | Text |
| Resource Type | Article |
