NDLI: Modulating the Interaction of Stromal-cell-derived Factor-1 / CXCL 12 and its Receptor , CXCR 4 , for Enhanced Mobilisation , Homing and Engraftment of Haematopoietic Stem Cells

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Modulating the Interaction of Stromal-cell-derived Factor-1 / CXCL 12 and its Receptor , CXCR 4 , for Enhanced Mobilisation , Homing and Engraftment of Haematopoietic Stem Cells

Content Provider	Semantic Scholar
Author	Campbel, Timothy B.
Copyright Year	2014
Abstract	Normal blood cell production – haematopoiesis – is crucial for the maintenance of health.1 Haematopoiesis is initiated through rare populations of haematopoietic stem (HSC) and progenitor (HPC) cells that give rise to all blood-forming elements: HSCs/HPCs are found in the bone marrow of adults, where they are produced and nurtured. HSCs/HPCs are also found in high numbers in umbilical cord blood (CB) at birth, and circulate in the peripheral blood of adults – although in very low numbers. Numbers of HSCs/HPCs in adult blood can be enhanced by mobilising them out of the bone marrow into the circulation by agents such as granulocyte colony-stimulating factor (G-CSF). Because normal HSCs/HPCs can be used in a transplant setting to cure non-malignant and malignant blood-cell – as well as other non-blood-cell – disorders, knowledge of how HSC/HPC movement is regulated has clinical impact.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.touchoncology.com/system/files/private/articles/19092/pdf/campbell_0.pdf
Language	English
Access Restriction	Open
Subject Keyword	Blood Cells Bone Marrow Colony-Stimulating Factors Filgrastim Granulocyte-Macrophage Colony-Stimulating Factor Hematopoiesis Hematopoietic System Hematopoietic stem cells Missile guidance Population Stimulation (motivation) Umbilical Cord Blood Umbilical cord structure Umbilicus (Anatomy) engraftment granulocyte peripheral blood receptor
Content Type	Text
Resource Type	Article

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