cell regulation of effector CD 8 T cell development for contact hypersensitivity responses

Content Provider	Semantic Scholar
Author	Kish, Danielle D. Gorbachev, Anton V. Fairchild, Robert L.
Copyright Year	2005
Abstract	Interleukin (IL)-2 functions to promote, as well as down-regulate, expansion of antigen-reactive CD4 and CD8 T cells, but the role of IL-2 in hapten-specific CD8 T cell priming for contact hypersensitivity (CHS) responses remains untested. Using enzyme-linked immunospot to enumerate numbers of hapten-specific CD4 and CD8 T cells producing IL-2 in hapten-sensitized mice, the number of IL-2-producing CD8 T cells was tenfold that of CD4 T cells. Hapten-primed CD4 T cells produced low amounts of IL-2 during culture with hapten-presenting Langerhans cells, whereas production by hapten-primed CD8 T cells was fivefold greater. CD8 T cells did not express CD25 during hapten priming, but treatment with anti-IL-2 or anti-CD25 monoclonal antibodies during hapten sensitization increased hapten-specific effector CD8 T cells as well as the magnitude and duration of the CHS response. These results indicate that CD8 T cells are the primary source of IL-2 and that this IL-2 is required for the function of a population of CD4 CD25 T cells to restrict the development of the hapten-reactive effector CD8 T cells that mediate CHS responses. J. Leukoc. Biol. 78: 725–735; 2005.
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Alternate Webpage(s)	http://www.jleukbio.org/content/78/3/725.full.pdf
Alternate Webpage(s)	http://www.jleukbio.org/content/early/2005/07/06/jlb.0205069.full.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article