Selected peripheral neuropathies associated with human immunodeficiency virus infection and antiretroviral therapy.

Content Provider	Semantic Scholar
Copyright Year	2002
Abstract	A variety of peripheral neuropathies are associated with human immunodeficiency virus (HIV) infection. Although the incidence of certain forms of neuropathy is increased in HIV infection, in other cases, the association may be fortuitous. Different forms of peripheral neuropathy occur with increased frequency at particular stages of HIV disease. For example, inflammatory demyelinating neuropathy (IDP) is often the first manifestation of HIV disease, when CD4 lymphocyte counts are relatively high. As immunosuppression progresses and HIV viral load becomes uncontrolled, the incidence of distal symmetrical polyneuropathy (DSP) increases. In advanced stages of HIV disease (CD4 count <50 cells/mm(3)), patients may develop opportunistic cytomegalovirus (CMV) nerve infection, which can present as progressive polyradiculopathy (PP) or mononeuropathy multiplex (MM). In addition to the neuromuscular disorders caused by HIV and its concomitant immunosuppression, the use of antiretroviral (ARV) drugs and other therapeutic agents in HIV disease is frequently limited by neuromuscular side effects. This paper will review the symmetrical forms of polyneuropathy that occur in association with HIV infection and nucleoside analogue therapy. The clinical, electrophysiologic, and pathologic features of these disorders will be described along with a discussion of theories of pathogenesis and results of treatment to date.
Starting Page	33
Ending Page	41
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurovirol.com/pdf/8(2s1)/33-41.pdf
PubMed reference number	12491149v1
Volume Number	8
Journal	Journal of neurovirology
Language	English
Access Restriction	Open
Subject Keyword	AIDS-Associated Nephropathy Acquired Immunodeficiency Syndrome Analog Antiretroviral therapy CD4 Antigens CD4 Count determination procedure Cytomegalovirus Infections Demyelinating peripheral neuropathy Facial Hemiatrophy HIV Enteropathy HIV Infections Immunologic Deficiency Syndromes Lymphocyte Count measurement Mononeuropathies Mononeuropathy Multiplex Neuromuscular Diseases Nucleoside Analogs Nucleosides Opportunistic Infections Patients Polyneuropathy Polyradiculopathy Therapeutic agent (substance) Virus Diseases nervous system disorder
Content Type	Text
Resource Type	Article